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The equilibrium ratio of thiol to thiolate forms varies with pH and is characteristic for specific thiol groups located within a distinct protein environment

As GPX4 or GSH deplete, ROS accumulation in cells can directly lead to lipid peroxidation

Their findings indicated that NAC (1000 mg/kg, intraperitoneally) effectively countered GSH depletion caused by 2-cyclohexene-1-one in both saline and amphetamine-treated rats

Further observations on the fine structure of freeze-cleaved tight junctions

Available at: Accessed 7/21/25

Substrates for GSTs include a broad range of endogenous and xenobiotic substances, including byproducts of oxidative stress, carcinogens and therapeutic drugs