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In this context, we propose that TBK1-mediated phosphorylation of GABARAPL2 at S10 acts as a negative regulatory termination signal

doi: 10.1073/pnas.2025000118

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During this process, which involves 10 enzymatically catalyzed steps, two molecules of ATP are expended ( investment stage) to build up a nearly symmetric intermediate, fructose-1,6-bisphosphate (Fru-1,6-BP), which is then cleaved ( splitting stage) to two three-carbon triose phosphates

The patients are often young and left with paralysis, spasticity and loss of sphincter control