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Moreover, it was postulated that the aromatic ring of the 3-homotyrosine side chain and the C-terminal phenyl ring interact and Phe550 in IRAP further stabilizes aromatic/hydrophobic packing ( More recently, a crystal structure of IRAP with the macrocyclic peptide inhibitor 23 (HA08) was reported (Mpakali et al., 2020)

This 15-amino-acid peptide, derived from a protective protein in human gastric juice, has demonstrated effects on nerve healing that go well beyond what its gastroprotective origins might suggest

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and M.J

The modifications are protective, not functional