padmini erythrocyte glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells Glutathione deficiency and heart failure:

This would also be advantageous in the translation of a protein containing multiple Sec residues such as selenoprotein P (5,11,13)

[DOI] [PMC free article] [PubMed] [Google Scholar] 210.Assimakopoulos S.F., Vagianos C.E., Zervoudakis G., Filos K.S., Georgiou C., Nikolopoulou V., Scopa C.D

Singh A, Kukreti R, Saso L, Kukreti S (2019) Oxidative stress: a key modulator in neurodegenerative diseases

Compare cost per milligram of reduced L-glutathione, not cost per bottle

Neoplasia 9 , 222235 (2007)

3 Key mechanistic pathways and synergistic actions In clinical application, TCM is often administered in multi-herbal formulations (7880), which typically involve multiple herbs targeting the same signaling pathway (78, 81) or a single herb acting through multiple mechanisms for the same disease (82, 83)