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Frequently Asked Questions How long did pigmentation changes take in clinical studies
doi: 10.1073/pnas.96.22.12766

Another pathognomonic feature of LAL-D is birefringent cholesterol ester crystals in hepatocytes and Kupffer cells, using polarized light on electron microscopy
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- As a result, supplementation is the only way to achieve the relatively high levels that have shown positive outcomes in clinical trials

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