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By mimicking this phosphorylated state, the S249/T252 peptide aims to disrupt the RB-NF-B interaction and inhibit NF-B-mediated PD-L1 transcription, thereby strengthening cancer immunity and overcoming immune evasion mechanisms triggered by both conventional and targeted therapies (Jin et al., 2019)

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However, in a report compiling data from 32 transplant centers from 1996 to 2009, survival and disease-free survival were as low as 62% and 20%, respectively, in patients with -thalassemia receiving CB cells from mismatched donors, after myeloablative conditioning [108]

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Exogenous glutamine supplementation is still used in the Intensive Care Unit to prevent post-operative complications