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However, several challenges persist

Based on the same loss-of-inhibition theory, an up-regulation of the excitatory neurotransmitter Glutamate (Glu) is suspected to play a role in disrupting the excitation/inhibition balance 11

However, these inhibitors may not be very selective, which could cause them to interact with other downstream signaling pathways and cause negative effects

Although metabolic products of tryptophan have been extensively studied in the intestinal environment, the effects of other products on renal fibrosis have not been widely reported

patients should be monitored more frequently for myelosuppression, renal toxicity, and gastrointestinal toxicity if concurrent ibuprofen cannot be avoided

M., Hegazy, U