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doi: 10.1080/10408398.2021.1913400

Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

While these responses are adaptive in the short term, prolonged exposure to high cortisol levels and chronic stress can lead to maladaptive outcomes such as immunosuppression, impaired growth, altered behaviour, and oxidative damage, leading to increased disease susceptibility and reduced performance [19, 83]

Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) injury which induces neuronal death[9]