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Another consequence of PK deficiency is the accumulation of glycolytic intermediates, such as 2,3-biphosphoglycerate (2,3-BPG)
78 Its also been shown to aid tendon and meniscus recovery after injury

This requires that different sets of genes are turned on, turned off, or tuned to the right levels in different cell types

Mutations blocking phosphorylation significantly enhance SOS1 binding

J., Kuhn, L

In this context, GlyT1 plays a key role in controlling extracellular glycine levels and, consequently, in modulating NMDA receptor activation