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BPC 157 activated the Src-Cav-1-eNOS signal pathway and reduced eNOS/Cav-1 binding in vascular endothelial cells It is known that phosphorylation of Src can promote Cav-1 activation and subsequent endocytosis of tyrosine kinase receptors and eNOS activation 20,24

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Nevertheless, the worldwide challenges of chitosan in drug nanoparticle technology remain, such as the limitation of the material source, time-consuming manufacture, unreliable production yield, and non-environmentally friendly synthesis due to the requirement of harsh chemical treatment (Kou et al., 2021)
