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Description
By the time an orally consumed peptide reaches the small intestine, most of it has been destroyed

However, some individuals may experience mild pain or discomfort at the injection site
As a result, B12 levels can either be abnormally high, due to the release of B12 from damaged liver cells, or low, due to reduced storage and release

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Onkologie 32 , 331336 (2009)

These early safety and pharmacokinetic studies preceded Phase 2 dose-ranging work in 20042006 and the Phase 3 pivotal trials that began in 2006
