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Bei andauerndem oxidativen Stress und Entstehung zu vieler ROS (reaktive Sauerstoff Spezies) verschiebt sich allerdings dieses Gleichgewicht und zieht ernsthaften Zellstress nach sich

doi: 10.1016/j.enzmictec.2020.109621 15 DelacuvellerieA.CyriaqueV.GobertS.BenaliS.WattiezR

Gusarov I, Shamovsky I, Pani B, Gautier L, Eremina S, Katkova-Zhukotskaya O, Mironov A, Makarov AA, Nudler E

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The latter enzyme converts pyruvate to acetate and is the rate-limiting step in the ultimate synthesis of the neurotransmitter acetylcholine

Consecutive 2-OMe moieties may be used to modify these motifs, and consecutive RNA or DNA nucleosides without additional 2 modifications may be employed for the bubble motif of GAAA
