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The discrepancy between demonstrated subcutaneous efficacy (or lack thereof) and marketed oral supplements creates a fundamental problem: commercially available AOD-9604 supplements likely deliver negligible systemic peptide due to oral bioavailability limitations

Whilst GLP-1 analogues are large peptide molecules that theoretically have limited transfer into milk, animal studies have demonstrated their presence in the milk of lactating rats

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[3] Cyanocobalamin, more common in oral supplements, contains a cyanide molecule that is released during metabolism