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Secondly, we conducted a series of pre-specified secondary and exploratory analyses based on mechanistic hypotheses about the neurobiological origins of such changes in schizophrenia and their clinical consequences

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Tirzepatide is a dual GIP/GLP-1 agonist with a slightly different molecular structure

Trimetazidine is being assessed for its efficacy in treating bipolar depression in an international multi-site clinical trial (Australian New Zealand Clinical Trials Registry registration: ACTRN12622000474752)