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We identify a compound that degrades MYC, A80.2HCl, which induces MYC degradation at nanomolar concentrations, restores pRB1 protein levels and re-establish sensitivity of MYC high-expressing cancer cells to CDK4/6i

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Molecular Formula: CHCuNO

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However, in complex diseases such as cancer, the efficacy of antioxidant therapy is often controversial and may even promote disease progression

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In addition, reports suggests EGCG may also influence hormonal aspects of acne since it is known to possess 5--reductase inhibiting properties when applied topically [28]

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In the hydrogen atom transfer mechanism, polyphenols donate a hydrogen atom from their phenolic hydroxyl group, producing free radicals that neutralize ROS (156)

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Author Contributions Study concept and design: Kumar, Pagali, Singh

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