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Oncol Lett 10:25842590 Kalayda GV, Wagner CH, Buss I, Reedijk J, Jaehde U (2008) Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells

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Dysregulation of Nrf2 expression is correlated with a disturbance in pancreatic and hepatic function and the development of oxidative stress [84]

Protein oxidation leads to structural modifications, loss of function, and aggregation of pathological proteins, such as beta-amyloid in AD and alpha-synuclein in PD, which disrupt intracellular processes and amplify neurotoxicity [79,80,81]