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These cells can modulate immune response and have shown influence on immune cell activity (83)

Harhaj NS, Felinski EA, Wolpert EB et al (2006) VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability

For more significant changes like improved skin brightness or enhanced immune response, several months of regular use may be necessary

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In very high doses, astaxanthin may cause a slight reddish tint to the skin (similar to eating too many carrots), and glutathione can occasionally cause mild digestive upset if not taken in a liposomal form

Skin tone usually returns gradually to its natural baseline if treatments are discontinued