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In a retrospective study of children with mitochondrial autism, 96% had markers of mitochondrial dysfunction in their blood: increased lactate level in 76% of the study group, an increase in pyruvate in 53%, an increased level of alanine in 36%, and CK activity was increased in 32% and 42% of the subjects who had abnormal organic acids in their urine [43]

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doi: 10.1016/j.ymgme.2004.02.004

Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women

All these effects induce cellular events including: (1) gene expression modifications, (2) hyperglycemia and dyslipidemia, (3) activation of oxidative stress and inflammatory response, (4) endothelial dysfunction, and (5) ectopic lipid accumulation, which, favored by obesity, perpetuates the metabolic deregulation