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They result from a combination of factors such as decreased collagen and elastin production, loss of hydration, and cumulative damage from environmental factors like UV exposure

So, we detected the ER stress in the current study to determine whether ER stress can be affected by 5-HT

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References Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al

In contrast, in the shRNA-TAUT cell cultures, no TAUT protein could be detected (Figure 5A)

That is 48.4 pounds total