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Despite these therapies not being initially designed to trigger cellular senescence, it was discovered as early as 1998 that cisplatin could induce cellular senescence in head and neck cancer cells [53]

While NPs like salvianolic acid show preclinical antifibrotic activity, their undefined targets and pharmacokinetics hinder clinical adoptiona stark contrast to approved synthetics like pirfenidone (2,403 mg/day) (Noble et al., 2011) and nintedanib (300 mg/day) (Richeldi et al., 2014), which themselves face tolerability limitations (Raghu et al., 2022a)

10.3109/08923973.2015.1115517 Immunopharmacol Immunotoxicol

[34] Speech therapy can improve voice quality

As such, this compound is primarily used in research settings to evaluate how structural modifications influence peptide behavior and biochemical interactions

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