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Histidyl (Histidine, H) : This essential amino acid has a unique side chain that can bind metal ions like copper, forming metalloproteins and peptides

Later, we will provide an in-depth analysis of these complex mechanisms, always from the perspective of neuroprotection

In the treated group, the GSH level, SOD and CAT activities can decrease compared to the control group, thus explaining the increased oxidative stress in the spleen (Sengupta et al., 2017)

The majority of GSH (90%) is found in the cytosol with a small but significant amount in the mitochondria and endoplasmic reticulum (ER) [10,11,12]

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Although the O-GlcNAc/Sp1 pathway is considered the main mechanism of the HSPs gene expression and production, glutamine may also act on HBP via p38/MAPK, leading to the HSPs expression in cells, such as neutrophils