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The physiology of brain histamine

R., Huang, E

It has been found that increased abundance of Enterococcus , Lactobacillus , and Bifidobacterium species in the gut can promote the production of neurotransmitters such as -aminobutyric acid (GABA), serotonin, dopamine, and acetylcholine, which are closely correlated with the gut microbiotabrain axis and help regulate anxiety and depression [104]

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Since GPX4 relies on GSH to neutralize lipid peroxides, lactate-driven metabolic reprogramming may indirectly compromise GPX4 efficiency, rendering PASMCs more susceptible to ferroptotic stimuli