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doi: 10.1038/srep33302

As CUD is an autosomal recessive disease, affected patients are expected to have two mutations, one on each of two chromosomes

For example, a preclinical tool based on fluorine 18-(2S,4R)-4-fluoroglutamine (FGln) PET has recently been developed for radiotracer imaging in the humans to identify abnormalities associated with glutamine metabolism in patients [177]

A total of 56 late-diagnosed congenital hypothyroid patients and 107 age-, sex-, and BMI-matched healthy controls were enrolled

On the other hand, APAP-exposure increases neither caspase-3 nor cleaved-caspase-3 expression which was consistent with previous research that caspase-3 might not play an effect in the APAP-induced liver injury 30 (Figure 5A and 5B)

T., Spiller, P., & Landa, M