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Despite extensive research, only a few synthetic antioxidants, such as edaravone, are currently used in clinical practice

Many studies have shown that certain biomaterials can provide three-dimensional structures suitable for stem cell growth to control undesirable migration, and can simultaneously be skilfully combined with biological factors or drugs that promote the differentiation of stem cells to NP cells, thereby promoting ECM secretion, inducing MSC differentiation to the NP cell phenotype, and accelerating IDD repair [91, 102, 103] (Fig

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LeclercqSMatamorosSCaniPDNeyrinckAMJamarFStrkelPet alIntestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity