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Acknowledgements This work was supported by NIH grant R01 CA79882 to JMS from the National Cancer Institute and by a Predoctoral Fellowship in Pharmacology by Pharmaceutical Research and Manufacturers of America Foundation awarded to Austin M Dulak

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It has been used in Chinese and Indian Ayurvedic medicine for over 2,000 years for its effectiveness in treating various pathological conditions, but in recent decades, it has come to our attention for its metabolic and cardiovascular health effects [75]