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Its water soluble so anything not used by the body is peed out

A 2019 study found that older adults supplementing high doses of vitamin B12 were at an increased risk of colon cancer

However, if 5-Amino-1MQ also improves insulin sensitivity (as suggested in animal models), combined use particularly alongside insulin or sulfonylureas could theoretically increase the risk of low blood sugar to a clinically significant degree

Genuine choline deficiency contributes to hepatic fat accumulation which is exactly why choline is in the blend and why the fat-metabolism story sounds plausible

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

You can eat enough B12 and still be low if your body doesnt absorb it well