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Particularly, the mRNA levels of Gcl-c, the first-rate limiting enzyme of glutathione synthesis, were already low in LivPGC-1 injected with saline, suggesting a possible negative correlation between coactivator and enzyme expression

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Poorly controlled diabetes during pregnancy also increases fetal risk

Although selenium was not measured in this study, adequate nutritional intake of selenium could potentially mask other differences between genotypes in this population

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