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Chronic obstructive pulmonary disease

Research protocols use frequent dosing or topical/oral routes to maintain target-tissue exposure

Ignores cellular levels: The total-B12 blood test fails to record whats happening at the cellular level

J Sex Med (2015) 12(4):96674

Specifically, acute and chronic prolonged wakefulness in mice induced by modafinil treatment produced LTP of glutamatergic synapses on hypocretin/orexin neurons in the lateral hypothalamus, a well-established arousal/wake-promoting center

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