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For gastrointestinal applications, digestive comfort may improve within the first 1 to 2 weeks, progressing to sustained improvements in food tolerances by weeks 5 to 6

Chen Y, Lewis W, Diwan A, Cheng EH, Matkovich SJ, Dorn GW

Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear

The appetite-suppression mechanism is what makes semaglutide so much more powerful than AOD-9604 for weight management