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the biological sample further comprises at least one compound (preferably at least two, more preferably all) selected from cysteine alkylated with the maleimide (such as NEM) or the heavy isotopologue thereof, glycine-cysteine dipeptide alkylated with the maleimide (such as NEM) or the heavy isotopologue thereof and insulin alkylated with the maleimide (such as NEM) or the heavy isotopologue thereof

Administration of radio-labeled proteins, such as insulin-like growth factor-1 (IGF-1) and interferon-beta 1b (IFN-1b), into the rat nose leads to their distribution along trigeminal and olfactory nerve associated pathways and dissemination into both rostral and caudal regions of the rat brain within 3060 min, thus providing evidence of rapid brain access of CNS acting drugs through intranasal delivery [32, 33]

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A single-institution, multidisciplinary approach to primary sarcomas involving the chest wall requiring full thickness resections

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