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Drug optimization, as a core aspect of drug development, aims to enhance the three key attributes of drugs through molecular structural modifications: biological activity, target selectivity and clinical safety

Here we show that a third, NADPH-independent pathway can bypass the need for TrxR1 and GR in mammalian liver

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Regulation of SIRT1/AMPK axis is critically involved in gallotannin-induced senescence and impaired autophagy leading to cell death in hepatocellular carcinoma cells