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This lower activity of these enzymes occur due to the Calvin cycle malfunctioning and the occurrence of photorespiration under drought stress, which caused greater accumulation of reactive oxygen species compared with the wild type (Koffler et al

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In a more recent study, we confirmed chronic HIF-1 stabilization in DBA/2 J mice could induce a pseudohypoxic state and, by doing so, promote hypoxia-induced mitophagy through elevated protein levels of BNIP3 (Nsiah et al., 2023)

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