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Furthermore, subchondral angiogenesis, often driven by VEGF and mechanical stress, disrupts the osteochondral interface and promotes cartilage deterioration (Grssel et al., 2021

Shelley AM, Ward PB, Catts SV, Michie PT, Andrews S, McConaghy N (1991)

Additionally, increased SAM availability supports methylation reactions essential for epigenetic regulation and polyamine synthesis, influencing cellular differentiation and metabolic programming