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Responders (92 patients) were randomized to receive four additional PCDE cycles plus thalidomide (400 mg daily) or placebo

2017)] in the plasma was not determined in the published study (Osawa et al

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This stable binding causes chemical alterations that are thought to contribute to drug toxicity either through changes in the functional properties of the modified molecules or through antigen formation with subsequent hypersensitivity and other immune reactions

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