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PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters

However, a growing body of research has uncovered that serine-driven one-carbon metabolism via the folate cycle contributes nearly as much to NADPH production as the PPP and malic enzymes in proliferating cells 19

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Breast milk contains sufficient amounts of vitamins and minerals to support normal infant growth during the first six months, with a few exceptions (such as vitamins D and K) [4, 34]

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This multi-level, multi-angle evidence chainfrom clinical observation to cell models and animal interventionscollectively supports ferroptosis as a critical link in OA cartilage pathology, with GPX4 dysfunction permeating this process