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Researchers should note that clinical studies on Fragment 176-191 to date have not involved administration via subcutaneous injection, but have employed infusion instead, as four escalating single doses of 25mcg 400mcg/kg, with a washout week between each administration [1]

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5.3 Clinical characteristics of the study population In the present review, most included ctDCS studies were conducted in healthy young adults, which restricts the applicability of their findings to clinical pain populations

doi: 10.1085/jgp.201912455 66 HoI

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