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They are generally not recommended during pregnancy or breastfeeding, for people with a known allergy to any component of the formulation, or for those with certain medical conditions

Vitamin B12 is typically found in food groups such as meats, such as poultry, fish, red meat, and even dairy products

Decreased uptake of [ 57 Co]-vitamin B 12 is indicative of impaired receptor-mediated endocytosis of holo-TC by the transcobalamin receptor

People with heavy menstrual bleeding may also be at higher risk of low B12 and iron

(2017) "Design and synthesis of NNMT inhibitors with tunable cell permeability." Published in Journal of Medicinal Chemistry