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Description
Gordon B, Fogel L, Varma G, et al
Keep vial sealed until use
Previous studies in other bacterial species, including Salmonella typhimurium ( 28 ) and Escherichia coli ( 29 ), showed that vitamin B12 repressed the expression of the cob/cbi operons in vitamin B12 biosynthesis pathway through cobalamin riboswitches
The Pernicious Anaemia Society notes this is recognised but not fully understood
Patients experiencing this may prefer evening administration to avoid daytime lethargy affecting work or daily activities
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