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This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects

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[DOI] [PMC free article] [PubMed] [Google Scholar] 174.Doorduijn D.J., Bardoel B.W., Heesterbeek D.A.C., Ruyken M., Benn G., Parsons E.S., Hoogenboom B.W., Rooijakkers S.H.M

This targeting has been demonstrated for the anti-MB protogenin (PRTG) CAR-T cells recognizing CSC of MB group 3 with a strong expression of PRTG (PRTG high ) and for the anti-PRTG blocking antibodies (329)

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Specifically, it was reported not to elevate IGF-1 and not to impair glucose tolerance or insulin sensitivity the very liabilities it was engineered to avoid