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Keywords: Autism, autism spectrum disorder (ASD), microglial activation, neuroinflammation, underconnectivity, early intervention, treatments EVIDENCE OF MICROGLIAL ACTIVATION AND BRAIN INFLAMMATION IN AUTISM A study by Johns Hopkins University School of Medicine found evidence of microglial activation in individuals with autism or autism spectrum disorder (ASD) (Pardo et al

doi: 10.1186/s12967-020-02600-9 121 ParkS

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Acta Physiol Oxf

Moreover, poor heart rate recovery (HRR), which is the difference between the peak heart rate during exercise and the heart rate soon afterwards is considered a more specific measure of parasympathetic withdrawal and is associated with increased mortality and adverse cardiovascular outcomes 5,6 Beta-blockers inhibit excess sympathetic stimulation and are one of the mainstays of the current treatment of HF with reduced ejection fraction