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doi:10.1021/cn400107y

Ehrlich AK, Pennington JM, Bisson WH, Kolluri SK, Kerkvliet NI

(2023) Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial

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These approaches enable systematic analysis of immune cell dynamics, cellcell interactions, and pathologic microenvironments within tissues, leading to a more comprehensive understanding of inflammatory phenotypes (Figure 6B) ( in silico pre-screening of natural products, with top candidate compounds subsequently validated in human organoidzebrafish chimera models