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Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

The peptide works through an entirely different mechanism involving beta-3 adrenergic receptors in adipose tissue, bypassing the growth hormone/IGF-1 axis completely

Abstract Background: Vitamin B12 deficiency is a widespread condition, particularly among elderly individuals, patients with malabsorption syndromes, and those following plant-based diets

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3-AR knockout mice: In 3-AR gene knockout mice, the lipolysis effect of AOD 9604 was significantly weakened, confirming that its effect depends on the 3-AR signaling pathway

personal (lecture) fees from Johnson & Johnson, Medtronic (formerly Covidien), Merck Sharpe & Dohme, ReShape Lifesciences (formerly Apollo-Endosurgery and Allergan Australia) and W.L