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Clinical studies have also found a 200-fold increased risk of HCC in people with iron overload, such as HH patients

[DOI] [PubMed] [Google Scholar] 52.Revesz C., Kaucsar T., Godo M., Bocskai K., Krenacs T., Mocsai A., Szenasi G., Hamar P

In sum, it is worthy to note that lipid peroxidation (LPO) products such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) arise as secondary messengers of oxidative stress, which is often counterbalanced by the cellular antioxidant defense system [133]

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3) Common pathophysiological mechanisms involving impaired SCFA production, immune-inflammatory activation, and dysregulated neuroactive metabolite metabolism