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These pathways have simultaneously developed for organ-specific adaptation to meet the physiological demands specific to each organ, sensing glucose in pancreatic -cells for insulin secretion, and sensing various nutrients like amino acids, fatty acids, and glucose for GLP-1 secretion in intestinal L-cells 32

M.QuirosY.VicenteL.MoralesA

doi: 10.1038/s41392-024-01772-w 106 ChenJJinZZhangSZhangXLiPYangHet al

238 ZIP1 and ZIP14 were found to be the most abundant influx transporters in pancreatic cells, while ZnT4, ZnT5, and ZnT8 were the dominant efflux transporters

[DOI] [PubMed] [Google Scholar] 122.Juang J.J., Binda A., Lee S.J., et al