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doi: 10.1155/2016/3643824.3643824 [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Mowry R., Winkler CH

104 However, this route presents significant challenges: the acidic environment of the GI tract can degrade peptides, and impaired intestinal absorptionparticularly in IBD patients with compromised digestive functionfurther reduces bioavailability

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This gray-market status creates a regulatory vacuum where responsibility for quality, purity, and safety falls to the individual user rather than health authorities