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Ethics statement The studies involving human participants were reviewed and approved by the Medical Ethics Committee of the Cliniques universitaires Saint-Luc (Brussels, Belgium)

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434 By transferring FFAs to cancer cells, adipocytes activate AMPK, induce mitochondrial fatty acid -oxidation and autophagy, and promote EMT, substantially enhancing tumor growth and survival

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And, clearly, there are shortcomings to the current drug-approval process