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In CRC, autophagy markers Beclin-1 and Ras-related in brain 7 (Rab-7) have been correlated with treatment resistance and poor survival (Koustas et al., 2019)

Shah PP, Kakar SS

[84] demonstrated reversal of premature aging in telomerase-deficient mice via inhibition of the Stc1/Akt signaling pathway, promoting apoptosis of senescent cells and reduction of p16INK4a/p21CIP1 expression

This improvement was attributed to the higher dose of TM administered, as the patient received double the standard dose of SLIT [84]

However, their clinical translation is impeded by their low bioavailability, poor stability, and inability to cross the BBB 25

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