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This means when you thaw it, the solution may no longer be a homogenous 0.9% concentration

Considerations for Patients with Malabsorption Disorders Those with malabsorption issues, like celiac disease or Crohns disease, might need more B12
Equation 6.6.2 Concentration at the End of an IV Infusion Once the infusion is stopped all we have is first order elimination
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10.1016/s0006-8993(01)02890-6 Brain Res

Bagchi D., editor
