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In addition, patients are selected on basis of treatment resistance defined as an insufficient response to 1 or more antidepressants given for at least 6 weeks in an adequate dose during the current episode

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The resulting solution will be a very dark, concentrated blue

This complex induces an increase in the expression of pro-apoptotic proteins such as Bax and Bad, and decreases other anti-apoptotic proteins such as Bcl-2 and Bax [46]

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233,298 As a representative cationic polymer, PEI is widely used in non-viral gene vectors in linear PEI (LPEI) or branched PEI (BPEI)