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When patients learn (sometimes the hard way) that using opioids will not give the high they are looking for and can cause 10/10 withdrawal sickness, its clearly not worth the relapse

But the science behind FTPP is far from dead

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Mitragynine was used as a surrogate for kratom due to being the most abundant alkaloid in the K51 product, 5 as well as a potent reversible inhibitor of CYP2D6 activity and time-dependent inhibitor of CYP3A activity in intestinal and/or liver microsomes

Studies published in the Journal of Clinical Psychopharmacology looked at the effects of GHB and alcohol on a group of volunteers